Neuropathic pain develops as a result of lesions or disease affecting the somatosensory nervous system either in the periphery or centrally examples of neuropathic pain include painful polyneuropathy postherpetic neuralgia trigeminal neuralgia and post stroke pain clinically neuropathic pain is characterised by spontaneous ongoing or shooting pain and evoked amplified pain responses . Introduction neuropathic pain or pain associated with disease or injury to the peripheral or central nervous system 1 is a common symptom of a heterogeneous group of conditions including diabetic neuropathy trigeminal neuralgia post herpetic neuralgia and spinal cord injury 2 the true prevalence of neuropathic pain is largely unknown because of the lack of proper epidemiologic studies. Core tip diabetic neuropathic pain is a common complication of diabetes and the most common form of neuropathic pain in this review we will discuss the various factors that may contribute to the pathogenesis of diabetic neuropathic pain including metabolic vascular autoimmune and oxidative stress related mechanisms. Neuropathic pain or nerve pain is one of the most intense types of chronic pain often described as sharp stinging or burningit is pain caused by damaged nerves or a problem with the nervous system while neuropathic pain can be debilitating the upside is that there are medications to treat it and they work by changing the way the brain interprets pain. Neuropathic pain is often described as a shooting or burning pain it can go away on its own but is often chronic sometimes it is unrelenting and severe and sometimes it comes and goes
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