In the present volume the first in the series the metabolism of drugs and other xenobiotics professor testa discusses the molecular and biochemical aspects of reactions of oxidation and reduction while an encyclopaedic treatment is avoided the covered topics include biochemical properties of the enzymes isoenzymes drug enzyme interactions . Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics these two volumes distinctly focus on the biochemistry with an emphasis on xenobiotic metabolizing enzymes their reactions and regulations the first volume is divided into three parts part one begins by introducing xenobiotics in the broad context of physiological metabolism and continues with . Surpassing the 1976 book by testa and jenner drug metabolism chemical and biochemical aspects dekker this informative up to date text includes the following features unavailable elsewhere first in a set of books to provide a comprehensive coverage of drug metabolism opening chapter provides a general introduction to the complete set of books other chapters cover reaction mechanisms . The biochemistry of drug metabolism an introduction part 1principles and overview by bernard testaa first oxidoreductases and their redox reactions oxidations and reductions part2 separation in this figureserving to draw a parallel with the main objectives of drug research in other words the three phases of drug disposition . In this article we offer an overview of the compared quantitative importance of biotransformation reactions in the metabolism of drugs and other xenobiotics based on a meta analysis of current research interests also we assess the relative significance the enzyme superfamilies or categories catalysing these reactions
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